Presented in part at: 15th Annual Angiogenesis, Exudation, and Degeneration meeting, February 2018, Miami, Florida; 41st Annual Macula Society Meeting, February 2018, Beverly Hills, California; Association for Research in Vision and Ophthalmology Annual Meeting, April–May 2018, Honolulu, Hawaii; Royal College of Ophthalmologists Annual Congress 2018, May 2018, Liverpool, United Kingdom; 36th World Ophthalmology Congress, June […]
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Initial Phase 1b data for KSI-301 in Wet AMD, DME, and RVO to be presented PALO ALTO, Calif., July 24, 2019 /PRNewswire/ — Kodiak Sciences Inc. (Nasdaq: KOD), a clinical-stage biopharmaceutical company specializing in novel therapeutics to treat chronic, high-prevalence retinal diseases, today announced that data from the ongoing KSI-301 clinical study will be presented […]
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In Brief: Symptomatic vitreomacular adhesion is associated with reduced visual acuity, which can significantly affect quality of life. This study was a prespecified analysis of the 2-year, sham-controlled OASIS trial. Clinically meaningful (≥5-point) changes in patient-reported outcomes were assessed. Ocriplasmin resulted in clinically meaningful improvements in visual function. Purpose: To evaluate patient-reported visual function after […]
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A Revolution in Retina – In the early 1990s when I applied for a surgical retina fellowship, the results of the two multicenter trials designed to test the efficacy of subfoveal laser photocoagulation in new and recurrent choroidal neovascularization in AMD were reported. This reaffirmed my decision to become a surgeon and confirmed my impressions […]
EARN CREDIT NOW Course Director: Pravin U. Dugel, MD Release Date: March 31, 2019 Expiration Date: March 31, 2020 Credits Available: Physicians – maximum of 0.5 AMA PRA Category 1 Credits™ Jointly provided by Postgraduate Institute for Medicine and Catamount Medical Education Supported by an independent educational grant from Novartis Pharmaceuticals Corporation Release Date: March […]
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Oxurion NV Reports Positive Topline Phase 1 Results with THR-149, a novel, potent plasma kallikrein inhibitor for the treatment of DME Topline data show that THR-149 is well-tolerated and safe. No dose-limiting toxicities or drug-related serious adverse events reported. Rapid onset of action starting at Day 1 with increasing average improvement in Best Corrected Visual […]
Purpose: The purpose of this article is to examine visual acuity (VA) outcomes and treatment patterns in neovascular age-related macular degeneration (nAMD) eyes switching between ranibizumab and aflibercept in routine clinical practice. Methods: Electronic medical records were used to identify nAMD eyes receiving ranibizumab or aflibercept with 12 months’ follow-up since switching antivascular endothelial growth […]
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Pravin U. Dugel, Adrian Koh, Yuichiro Ogura, Glenn Jaffe, Ursula Schmidt-Erfurth, David Brown, Andre V. Gomes, James Warburton, Andreas Weichselberger, Frank G. Holz Abstract ObjectiveTwo similarly designed, phase 3 trials (HAWK and HARRIER) compared brolucizumab, a single-chain antibody fragment that inhibits vascular endothelial growth factor-A, with aflibercept to treat neovascular age-related macular degeneration (AMD). DesignDouble-masked, multicenter, active-controlled, randomized trials. Patients(N = 1817) with untreated, […]
RWC Unplugged offers participants a unique opportunity to learn, share and discuss controversial topics in retina with a large group of industry experts and clinical leaders. With no scripts or industry commercials, this event evokes deep discussions moderated by KOLs, who encourage attendees to challenge their perspectives in lively, no-holds-barred discussions, with live polling on […]
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ReNeuron Group plc (AIM: RENE), a UK-based global leader in the development of cell-based therapeutics, is pleased to provide an update on progress with the ongoing Phase I/II clinical trial of its hRPC cell therapy candidate in the blindness-causing disease, retinitis pigmentosa (RP). The Company is pleased to report that all three of the first […]
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Pravin U. Dugel MD: Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema
/ Uncategorized /by retinalconsultantsPresented in part at: 15th Annual Angiogenesis, Exudation, and Degeneration meeting, February 2018, Miami, Florida; 41st Annual Macula Society Meeting, February 2018, Beverly Hills, California; Association for Research in Vision and Ophthalmology Annual Meeting, April–May 2018, Honolulu, Hawaii; Royal College of Ophthalmologists Annual Congress 2018, May 2018, Liverpool, United Kingdom; 36th World Ophthalmology Congress, June […]
Pravin U. Dugel, MD – Kodiak Sciences Announces Upcoming Presentation at American Society of Retina Specialists (ASRS) 2019 Annual Meeting
/ Uncategorized /by retinalconsultantsInitial Phase 1b data for KSI-301 in Wet AMD, DME, and RVO to be presented PALO ALTO, Calif., July 24, 2019 /PRNewswire/ — Kodiak Sciences Inc. (Nasdaq: KOD), a clinical-stage biopharmaceutical company specializing in novel therapeutics to treat chronic, high-prevalence retinal diseases, today announced that data from the ongoing KSI-301 clinical study will be presented […]
Patient-Reported Visual Function from Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion, Including Macular Hole (Oasis) Study
/ Uncategorized /by retinalconsultantsIn Brief: Symptomatic vitreomacular adhesion is associated with reduced visual acuity, which can significantly affect quality of life. This study was a prespecified analysis of the 2-year, sham-controlled OASIS trial. Clinically meaningful (≥5-point) changes in patient-reported outcomes were assessed. Ocriplasmin resulted in clinically meaningful improvements in visual function. Purpose: To evaluate patient-reported visual function after […]
Pravin U. Dugel, MD: Guest Editor, Ophthalmology Management July 2019 Issue
/ Uncategorized /by retinalconsultantsA Revolution in Retina – In the early 1990s when I applied for a surgical retina fellowship, the results of the two multicenter trials designed to test the efficacy of subfoveal laser photocoagulation in new and recurrent choroidal neovascularization in AMD were reported. This reaffirmed my decision to become a surgeon and confirmed my impressions […]
Pravin U. Dugel MD: 1,800 Seconds™ in Advances in the Management of Age-Related Macular Degeneration
/ Uncategorized /by retinalconsultantsEARN CREDIT NOW Course Director: Pravin U. Dugel, MD Release Date: March 31, 2019 Expiration Date: March 31, 2020 Credits Available: Physicians – maximum of 0.5 AMA PRA Category 1 Credits™ Jointly provided by Postgraduate Institute for Medicine and Catamount Medical Education Supported by an independent educational grant from Novartis Pharmaceuticals Corporation Release Date: March […]
Dr. Pravin U. Dugel: Oxurion NV Reports Positive Topline Phase 1 Results with THR-149
/ Uncategorized /by retinalconsultantsOxurion NV Reports Positive Topline Phase 1 Results with THR-149, a novel, potent plasma kallikrein inhibitor for the treatment of DME Topline data show that THR-149 is well-tolerated and safe. No dose-limiting toxicities or drug-related serious adverse events reported. Rapid onset of action starting at Day 1 with increasing average improvement in Best Corrected Visual […]
Pravin U. Dugel, MD: Clinical Effectiveness of Switching Between Ranibizumab and Aflibercept in Treatment of Neovascular AMD: US Real-World Outcomes
/ Uncategorized /by retinalconsultantsPurpose: The purpose of this article is to examine visual acuity (VA) outcomes and treatment patterns in neovascular age-related macular degeneration (nAMD) eyes switching between ranibizumab and aflibercept in routine clinical practice. Methods: Electronic medical records were used to identify nAMD eyes receiving ranibizumab or aflibercept with 12 months’ follow-up since switching antivascular endothelial growth […]
Dr. Pravin U. Dugel – HAWK and HARRIER: Phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration
/ Uncategorized /by retinalconsultantsPravin U. Dugel, Adrian Koh, Yuichiro Ogura, Glenn Jaffe, Ursula Schmidt-Erfurth, David Brown, Andre V. Gomes, James Warburton, Andreas Weichselberger, Frank G. Holz Abstract ObjectiveTwo similarly designed, phase 3 trials (HAWK and HARRIER) compared brolucizumab, a single-chain antibody fragment that inhibits vascular endothelial growth factor-A, with aflibercept to treat neovascular age-related macular degeneration (AMD). DesignDouble-masked, multicenter, active-controlled, randomized trials. Patients(N = 1817) with untreated, […]
Dr. Pravin U. Dugel Chairs Retina World Congress Unplugged
/ Uncategorized /by retinalconsultantsRWC Unplugged offers participants a unique opportunity to learn, share and discuss controversial topics in retina with a large group of industry experts and clinical leaders. With no scripts or industry commercials, this event evokes deep discussions moderated by KOLs, who encourage attendees to challenge their perspectives in lively, no-holds-barred discussions, with live polling on […]
Positive preliminary data in US retinal trial: Significant improvement in vision in first cohort of Phase II subjects in US trial of hRPC cell therapy in retinitis pigmentosa
/ Uncategorized /by retinalconsultantsReNeuron Group plc (AIM: RENE), a UK-based global leader in the development of cell-based therapeutics, is pleased to provide an update on progress with the ongoing Phase I/II clinical trial of its hRPC cell therapy candidate in the blindness-causing disease, retinitis pigmentosa (RP). The Company is pleased to report that all three of the first […]